| dc.description.abstract | The genus Ficus is one of the largest genera of angiosperms with more than 800 species.
This study aimed at investigating the pharmacological properties of Ficus carica linn. Leaves were
collected in two seasons (May and October) and were extracted by Soxhlet extractor with different
percentages of methanol-water, ethanol-water and pure water solvents. 100% methanol and 95%
ethanol offered the highest yield (about 23%). Those extracts were further extracted/partitioned with nbutanol.
May samples showed higher TPC, TFC and AA results than October samples. The ethanolbutanol
extract had the highest TPC results (150.7±0.5 mg GA/g extract), while methanol-butanol
extract showed the highest results for TFC and AA (350±4.3 mg Rutin/g extract and 368.1±1.9 mg
FeSO4/g extract, respectively). Ethanol and methanol extracts were weakly active against E. coli, while
the extracts showed good inhibition activity against oral flora, where October samples gave higher
activity than May samples. Some components of extracts were analyzed by a newly developed HPLCPDA
method. Eight compounds were identified: chlorogenic acid, caffeic acid, syringic acid, coumaric
acid, rutin and trans-cinnamic acid. Quercetin was identified after acid hydrolysis of extracts in all
sample extracts, while ferulic acid was present in water extract only | en_US |
